Hong Wang

Hong Wang

Company: Sanofi

Job title: Statistical Biomarker Lead


Joint Modeling of Safety & ctDNA to Support Recommended Phase 2 Dose Identification in Phase 1 Study 1:50 pm

Circulating tumor DNA (ctDNA)-based molecular response has been shown to predict clinical response earlier than RECIST response and is associated with long-term survival with different therapies across solid tumor types Beyond dose-limiting toxicity (DLT), pharmacodynamic markers or pharmacokinetics can be used to help identify optimal dosing of biologics   We used an innovative integrative approach that…Read more

day: Day 1 Track B PM

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