Doris Kim

Company: Zentalis Pharmaceuticals

Job title: Vice President - Translational Sciences

Seminars:

Characterizing the Predictive Value of Cyclin E1 Protein Expression to a WEE1 Inhibitor, Azenosertib (ZN-c3) 2:00 pm

CCNE1 gene amplification is a prevalent oncogenic driver in high grade serous ovarian cancer (HGSOC) and is associated with platinum resistance and poor patient outcomes. Importantly, Cyclin E1 overexpression can also occur in both the presence and absence of gene amplification Increased levels of Cyclin E1 results in accumulation of replication stress markers and showed…Read more

day: Day Two Track A