Tim Heffernan

Tim Heffernan

Company: MD Anderson Cancer Center- Translational Research to Advance Therapeutics & Innovation in Oncology

Job title: Executive Director, Oncology Research


Translational Case Study: Translational Development of IACS-6274, a Potent and Selective Glutaminase (GLS1) Inhibitor in Phase 1 Trials for Molecularly-Defined Subsets of Patients with Advanced Solid Tumors 8:00 am

IACS-6274 is a potent, selective inhibitor of GLS1, that has excellent physicochemical properties and demonstrates selective anti-tumor effects in subsets of ovarian cancer and non-small cell lung cancers Through a comprehensive translational effort, we uncovered a reliance on GLS1 driven by unique cellular dependencies and identified clinically actionable patient stratification biomarkers An integrated approach that…Read more

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